![]() Age and diabetes were notable factors associated with dementia after TGA.ĭementia Hippocampus Neuroepidemiology Transient global amnesia. TGA increased the long-term risk of dementia. Age and diabetes were significantly associated with dementia in TGA. The adjusted HR for dementia in TGA cohorts was 2.23 (95% CI 1.12-4.44, p = 0.023) compared with non-TGA cohorts after adjusting for age, gender and comorbidities. There were 14 dementia cases in the 181 TGA cohorts during the follow-up period with yearly incidence rates of 20.14 per 1,000 person. The patient is usually over 50 years old and an attack may last several hours. The risk factors of dementia after TGA were investigated.Ī total of 181 TGA subjects and 543 non-TGA controls were included in the study. Transient global amnesia (TGA) is a temporary and isolated disorder of memory. The cumulative hazard ratio (HR) of dementia was estimated. The yearly incidence of dementia was compared in TGA and non-TGA cohorts. Other articles where transient global amnesia is discussed: memory abnormality: Transient global amnesia: Apparently first described in 1964, transient. From all potential participants >18 years of age without dementia history, we identified TGA subjects and non-TGA controls with age, gender and comorbidities matched in a 1:3 ratio. We conducted a control cohort study using the Taiwan National Health Insurance Research database from 2005 to 2012 with an 8-year follow-up period. We aimed to investigate the long-term risk of dementia up to 8 years in subjects with TGA. All rights reserved.Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of larger anterograde and milder retrograde amnesia that lasts up to 24 h. Our findings indicate that having an episode of TGA does not increase the risk of subsequent cerebrovascular events, seizures, or cognitive impairment.Ĭopyright © 2016 Mayo Foundation for Medical Education and Research. ![]() Modified Rankin scale and death rates at last follow-up were also similar between both groups. The TGA recurrence occurred in 5.4% of patients after a median interval of 4.21 years (interquartile range, 2.82-8.44). There was no statistically significant difference between survival curves for the TGA group and the control group using time to any type of cerebrovascular event (log-rank P=.30), time to seizures event (log-rank P=.55), and time to cognitive impair event (log-rank P=.88) as end points. Previous migraine was more common in the TGA group (42 patients vs 12 patients P<.001). Prevalence of vascular risk factors and history of seizures were similar between both groups. The mean duration of follow-up was 12 years in both groups (range, 0.07-29.93). If you develop it, you’ll experience confusion or agitation that comes and goes repeatedly over the course of several hours. End points were studied using Kaplan-Meier survival plots and log-rank test.Ī total of 221 patients with TGA were identified and 221 age- and sex-matched controls were included in the analysis. Transient global amnesia (TGA) is a poorly understood condition. End points were cerebrovascular event (stroke or transient ischemic attack), seizure, or cognitive impairment (mild cognitive impairment or dementia) during follow-up. Transient global amnesia was defined clinically. To study the long-term risk of cerebrovascular events, seizures, and cognitive impairment in patients with transient global amnesia (TGA).ĭata for all patients diagnosed with possible TGA in Olmsted County, Minnesota, between January 1, 1985, through December 31, 2010, were retrieved from the Rochester Epidemiology Project database.
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